Aleksandra  Badura

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Dr. Aleksandra Badura

Biography

Throughout my Ph.D. studies and Postdoctoral Fellowships my work had focused on unraveling the function of the cerebellum in health and disease, encompassing two research lines: Line-1 integrated experimental techniques with modeling to investigate the mechanisms of cerebellar learning. I have established that the modulation of cerebellar activity is essential for motor learning and helped to develop a computer model that reproduces experimental data and can predict motor impairments based on neural activity. Using intravital two-photon imaging, we discovered that granule cells acquire signals predictive of motor performance . This marked a paradigm shift in the understanding of cerebellar coding. We are working on incorporating those findings into our model. Furthermore, I have developed tools for monitoring neuronal activity that advance two-photon imaging. In Line-2, I investigated the role of the cerebellum in autism spectrum disorder (ASD). We showed that cerebellar deficits are common in ASD. Recently, by disrupting cerebellar activity during different stages of development, we established a critical period during which specific cerebellar regions are crucial for non-motor behaviors. This work has been made possible by the VENI-ZonMw grant. In June 2018 I was awarded a VIDI-ZonMw grant to work on understanding the cerebello-cerebral networks underlying shared autistic traits.

Publications

Normal cognitive and social development require posterior cerebellar activity

in eLife
Badura A., Verpeut J.L., Metzger J.W, Pereira T.D, Pisano T.J., Deverett B., Bakshinskaya D.E., Wang S.S.-H
DOI: 10.7554/eLife.36401

Cerebellar Granule Cells: Dense, Rich and Evolving Representations.

Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning.

in Nature neuroscience
Giovannucci A, Badura A, Deverett B, Najafi F, Pereira TD, Gao Z, Ozden I, Kloth AD, Pnevmatikakis E, Paninski L, De Zeeuw CI, Medina JF, Wang SS
DOI: 10.1038/nn.4531

Modeled changes of cerebellar activity in mutant mice are predictive of their learning impairments.

in Scientific reports
Badura A, Clopath C, Schonewille M, De Zeeuw CI
DOI: 10.1038/srep36131

Cerebellar associative sensory learning defects in five mouse autism models.

in eLife
Kloth A.D., Badura A., Li A., Cherskov A., Connolly S.G., Giovannucci A., Bangash M.A., Grasselli G., Peñagarikano O., Piochon C., Tsai P.T, Geschwind D.H., Hansel C., Sahin M., Takumi T, Worley P.F.,Wang S.S.-H
DOI: 10.7554/eLife.06085

A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice.

in The Journal of neuroscience : the official journal of the Society for Neuroscience
Clopath C, Badura A, De Zeeuw CI, Brunel N
DOI: 10.1523/JNEUROSCI.2791-13.2014

A cerebellar learning model of Vestibulo-Ocular Reflex adaptation in wild-type and mutant mice

in Journal of Neuroscience
Clopath, C., Badura, A., De Zeeuw, C. I. and Brunel, N.

Climbing fiber input shapes reciprocity of Purkinje cell firing.

in Neuron
Badura A, Schonewille M, Voges K, Galliano E, Renier N, Gao Z, Witter L, Hoebeek FE, Chédotal A, De Zeeuw CI
DOI: 10.1016/j.neuron.2013.03.018

Genetic dissection of the function of hindbrain axonal commissures

in PLoS Biol
Renier N, Schonewille M, Giraudet F, Badura A, Tessier-Lavigne M, Avan P, De Zeeuw CI, Chédotal A

Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning.

in Neuron
Schonewille M, Belmeguenai A, Koekkoek SK, Houtman SH, Boele HJ, van Beugen BJ, Gao Z, Badura A, Ohtsuki G, Amerika WE, Hosy E, Hoebeek FE, Elgersma Y, Hansel C, De Zeeuw CI
DOI: 10.1016/j.neuron.2010.07.009
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Education

2011

PhD in Neuroscience

in Erasmus University (the Netherlands)

2006

Masters Degree in Psychology

in Jagiellonian University (Poland)

Honors & Awards

2018

Vidi NWO

ZonMw

2014

Veni NWO

ZonMw

2005

Erasmus Exchange Program

EU