Femke  de Vrij

contact

  • f.devrij@erasmusmc.nl
  • +31 010 70 41191
  • Room: Ee-1432
  • Dr. Molewaterplein 40, Faculty Building, Rotterdam, The Netherlands

Femke de Vrij (F.M.S.)

  • PhD
  • Assistant Professor
  • Erasmus MC

Publications

Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia.

in Molecular psychiatry
de Vrij FM, Bouwkamp CG, Gunhanlar N, Shpak G, Lendemeijer B, Baghdadi M, Gopalakrishna S, Ghazvini M, Li TM, Quadri M, Olgiati S, Breedveld GJ, Coesmans M, Mientjes E, de Wit T, Verheijen FW, Beverloo HB, Cohen D, Kok RM, Bakker PR, Nijburg A, Spijker AT, Haffmans PMJ, Hoencamp E, Bergink V, Vorstman JA, Wu T, Olde Loohuis LM, Amin N, Langen CD, Hofman A, Hoogendijk WJ, van Duijn CM, Ikram MA, Vernooij MW, Tiemeier H, Uitterlinden AG, Elgersma Y, Distel B, Gribnau J, White T, Bonifati V, Kushner SA
DOI: 10.1038/s41380-017-0004-2

Employed family-based genetic discovery combining linkage analysis and exome sequencing to identify RCL1 as a novel candidate gene for depression, with independent replication in a population-based cohort.

in Molecular psychiatry
Amin N, de Vrij FMS, Baghdadi M, Brouwer RWW, van Rooij JGJ, Jovanova O, Uitterlinden AG, Hofman A, Janssen HLA, Murad SD, Kraaij R, Stedehouder J, van den Hout MCGN, Kros JM, van IJcken WFJ, Tiemeier H, Kushner SA, van Duijn CM
DOI: 10.1038/mp.2018.6

The Zinc Transporter SLC39A7 (ZIP7) Is Essential for Regulation of Cytosolic Zinc Levels.

in Molecular pharmacology
Woodruff G, Bouwkamp CG, de Vrij FM, Lovenberg T, Bonaventure P, Kushner SA, Harrington AW
DOI: 10.1124/mol.118.112557

Homozygous missense mutation associated with complicated hereditary spastic paraplegia

in Neurology. Genetics
Bouwkamp CG, Afawi Z, Fattal-Valevski A, Krabbendam IE, Rivetti S, Masalha R, Quadri M, Breedveld GJ, Mandel H, Tailakh MA, Beverloo HB, Stevanin G, Brice A, van IJcken WFJ, Vernooij MW, Dolga AM, de Vrij FMS, Bonifati V, Kushner SA
DOI: 10.1212/NXG.0000000000000223

SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells.

in Stem cell reports
García-León JA, Kumar M, Boon R, Chau D, One J, Wolfs E, Eggermont K, Berckmans P, Gunhanlar N, de Vrij F, Lendemeijer B, Pavie B, Corthout N, Kushner SA, Dávila JC, Lambrichts I, Hu WS, Verfaillie CM
DOI: 10.1016/j.stemcr.2017.12.014

An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum.

in Scientific reports
Higuera GA, Iaffaldano G, Bedar M, Shpak G, Broersen R, Munshi ST, Dupont C, Gribnau J, de Vrij FMS, Kushner SA, De Zeeuw CI
DOI: 10.1038/s41598-017-09348-1

Phenotypic Differences between Asian and African Lineage Zika Viruses in Human Neural Progenitor Cells.

in mSphere
Anfasa F, Siegers JY, van der Kroeg M, Mumtaz N, Stalin Raj V, de Vrij FMS, Widagdo W, Gabriel G, Salinas S, Simonin Y, Reusken C, Kushner SA, Koopmans MPG, Haagmans B, Martina BEE, van Riel D
DOI: 10.1128/mSphere.00292-17

A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells.

in Molecular psychiatry
Gunhanlar N, Shpak G, van der Kroeg M, Gouty-Colomer LA, Munshi ST, Lendemeijer B, Ghazvini M, Dupont C, Hoogendijk WJG, Gribnau J, de Vrij FMS, Kushner SA
DOI: 10.1038/mp.2017.56

The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals.

in The EMBO journal
Vanhauwaert R, Kuenen S, Masius R, Bademosi A, Manetsberger J, Schoovaerts N, Bounti L, Gontcharenko S, Swerts J, Vilain S, Picillo M, Barone P, Munshi ST, de Vrij FM, Kushner SA, Gounko NV, Mandemakers W, Bonifati V, Meunier FA, Soukup SF, Verstreken P
DOI: 10.15252/embj.201695773

A rare missense variant in RCL1 segregates with depression in extended families.

in Molecular psychiatry
Amin N, de Vrij FMS, Baghdadi M, Brouwer RWW, van Rooij JGJ, Jovanova O, Uitterlinden AG, Hofman A, Janssen HLA, Darwish Murad S, Kraaij R, Stedehouder J, van den Hout MCGN, Kros JM, van IJcken WFJ, Tiemeier H, Kushner SA, van Duijn CM
DOI: 10.1038/mp.2017.49
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