Geeske  van Woerden

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Dr. Geeske van Woerden (GM)

Publications

Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome.

in Frontiers in cellular neuroscience
Wang T, van Woerden GM, Elgersma Y, Borst JGG
DOI: 10.3389/fncel.2017.00418

A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel mutants.

in Molecular autism
Sonzogni M, Wallaard I, Santos SS, Kingma J, du Mee D, van Woerden GM, Elgersma Y
DOI: 10.1186/s13229-018-0231-7

The intellectual disability-associated CAMK2G p.Arg292Pro mutation acts as a pathogenic gain-of-function

in Hum Mutat
Proietti Onori M, Koopal B, Everman DB, Worthington JD, Jones JR, Ploeg MA, Mientjes E, van Bon BW, Kleefstra T, Schulman H, Kushner SA, Küry S, Elgersma Y, van Woerden GM
DOI: 10.1002/humu.23647

Adult Ube3a Gene Reinstatement Restores the Electrophysiological Deficits of Prefrontal Cortex Layer 5 Neurons in a Mouse Model of Angelman Syndrome

Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability.

in Nature communications
Reijnders MRF, Kousi M, van Woerden GM, Klein M, Bralten J, Mancini GMS, van Essen T, Proietti-Onori M, Smeets EEJ, van Gastel M, Stegmann APA, Stevens SJC, Lelieveld SH, Gilissen C, Pfundt R, Tan PL, Kleefstra T, Franke B, Elgersma Y, Katsanis N, Brunner HG
DOI: 10.1038/s41467-017-00933-6

Ub3a loss increases excitability and blunts orientation tuning in the visual cortex of Angelman syndrome model mice.

in Journal of neurophysiology
Wallace ML, van Woerden GM, Elgersma Y, Smith SL, Philpot BD
DOI: 10.1152/jn.00618.2016

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability

in Am J Hum Genet
Küry S, van Woerden GM, Besnard T, Proietti Onori M, Latypova X, Towne MC, Cho MT, Prescott TE, Ploeg MA, Sanders S, Stessman HAF, Pujol A, Distel B, Robak LA, Bernstein JA, Denommé-Pichon AS, Lesca G, Sellars EA, Berg J, Carré W, Busk ØL, van Bon BWM, Waugh JL, Deardorff M, Hoganson GE, Bosanko KB, Johnson DS, Dabir T, Holla ØL, Sarkar A, Tveten K, de Bellescize J, Braathen GJ, Terhal PA, Grange DK, van Haeringen A, Lam C, Mirzaa G, Burton J, Bhoj EJ, Douglas J, Santani AB, Nesbitt AI, Helbig KL, Andrews MV, Begtrup A, Tang S, van Gassen KLI, Juusola J, Foss K, Enns GM, Moog U, Hinderhofer K, Paramasivam N, Lincoln S, Kusako BH, Lindenbaum P, Charpentier E, Nowak CB, Cherot E, Simonet T, Ruivenkamp CAL, Hahn S, Brownstein CA, Xia F, Schmitt S, Deb W, Bonneau D, Nizon M, Quinquis D, Chelly J, Rudolf G, Sanlaville D, Parent P, Gilbert-Dussardier B, Toutain A, Sutton VR, Thies J, Peart-Vissers LELM, Boisseau P, Vincent M, Grabrucker AM, Dubourg C; Undiagnosed Diseases Network, Tan WH, Verbeek NE, Granzow M, Santen GWE, Shendure J, Isidor B, Pasquier L, Redon R, Yang Y, State MW, Kleefstra T, Cogné B; GEM HUGO; Deciphering Developmental Disorders Study, Petrovski S, Retterer K, Eichler EE, Rosenfeld JA, Agrawal PB, Bézieau S, Odent S, Elgersma Y, Mercier S
DOI: 10.1016/j.ajhg.2017.10.003

Impaired Neurite Contact Guidance in Ubiquitin Ligase E3a (Ube3a)-Deficient Hippocampal Neurons on Nanostructured Substrates.

in Advanced healthcare materials
Tonazzini I, Meucci S, Van Woerden GM, Elgersma Y, Cecchini M
DOI: 10.1002/adhm.201500815

GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility

in Neuron
Judson, M. C., Wallace, M. L., Sidorov, M. S., Burette, A. C., Gu, B., van Woerden, G. M., King, I. F., Han, J. E., Zylka, M. J., Elgersma, Y., Weinberg, R. J. and Philpot, B. D.

The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion

in Scientific Reports
Kool, M. J., Van De Bree, J. E., Bodde, H. E., Elgersma, Y. and Van Woerden, G. M.
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