Cortico Cerebellar Communication

Lab Members

Zhenyu Gao
Dr. Zhenyu Gao (Z.)
Assistant Professor
Lab Head
Bibi Bouwen
Bibi Bouwen
Phd Student
Hana Hasanbegovic
Hana Hasanbegovic
Phd Student
Jort van Rij
Jort van Rij
Master Student
Zhong Ren
Zhong Ren
Master Student

Recent Publications

The impacts of tumor and tumor associated epilepsy on subcortical brain structures and long distance connectivity in patients with low grade glioma

Bouwen BLJ , Pieterman KJ, Smits M, Dirven CMF, Gao Z, Vincent AJPE
in Frontiers in Neurology 2018

The basal interstitial nucleus (BIN) of the cerebellum provides diffuse ascending inhibitory input to the floccular granule cell layer.

Jaarsma D, Blot FGC, Wu B, Venkatesan S, Voogd J, Meijer D, Ruigrok TJH, Gao Z, Schonewille M, De Zeeuw CI
in The Journal of comparative neurology 2018

A cortico-cerebellar loop for motor planning.

Gao Z, Davis C, Thomas AM, Economo MN, Abrego AM, Svoboda K, De Zeeuw CI, Li N
in Nature 2018

Impact of parallel fiber to Purkinje cell long-term depression is unmasked in absence of inhibitory input.

Boele HJ, Peter S, Ten Brinke MM, Verdonschot L, IJpelaar ACH, Rizopoulos D, Gao Z, Koekkoek SKE, De Zeeuw CI
in Science advances 2018

Dynamic modulation of activity in cerebellar nuclei neurons during pavlovian eyeblink conditioning in mice.

Ten Brinke MM, Heiney SA, Wang X, Proietti-Onori M, Boele HJ, Bakermans J, Medina JF, Gao Z, De Zeeuw CI
in eLife 2017

Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning.

Giovannucci A, Badura A, Deverett B, Najafi F, Pereira TD, Gao Z, Ozden I, Kloth AD, Pnevmatikakis E, Paninski L, De Zeeuw CI, Medina JF, Wang SS
in Nature neuroscience 2017

Excitatory Cerebellar Nucleocortical Circuit Provides Internal Amplification during Associative Conditioning.

Gao Z, Proietti-Onori M, Lin Z, Ten Brinke MM, Boele HJ, Potters JW, Ruigrok TJ, Hoebeek FE, De Zeeuw CI
in Neuron 2016

Distinct roles of α-and βCaMKII in controlling long-term potentiation of GABAA-receptor mediated transmission in murine Purkinje cells

Gao Z, van Woerden G, Elgersma Y, De Zeeuw C, Hoebeek F
in Frontiers in cellular neuroscience 2014

Distinct roles of α- and βCaMKII in controlling long-term potentiation of GABAA-receptor mediated transmission in murine Purkinje cells

Gao, Z., van Woerden, G. M., Elgersma, Y., De Zeeuw, C. I. and Hoebeek, F. E.
in Frontiers in Cellular Neuroscience 2014

Cerebellar modules operate at different frequencies

Zhou, H., Lin, Z., Voges, K., Ju, C., Gao, Z., Bosman, L. W. J., Ruigrok, T. J., Hoebeek, F. E., De Zeeuw, C. I. and Schonewille, M
in eLife 2014

Climbing fiber input shapes reciprocity of Purkinje cell firing.

Badura A, Schonewille M, Voges K, Galliano E, Renier N, Gao Z, Witter L, Hoebeek FE, Chédotal A, De Zeeuw CI
in Neuron 2013

High frequency burst firing of granule cells ensures transmission at the parallel fiber to purkinje cell synapse at the cost of temporal coding.

van Beugen BJ, Gao Z, Boele HJ, Hoebeek F, De Zeeuw CI
in Frontiers in neural circuits 2013

Silencing the majority of cerebellar granule cells uncovers their essential role in motor learning and consolidation

Galliano E, Gao Z, Schonewille M, Todorov B, Simons E, Pop AS, D'Angelo E, van den Maagdenberg AM, Hoebeek FE, De Zeeuw CI.
in Cell Reports 2013

Distributed synergistic plasticity and cerebellar learning

Gao Z, Beugen B, De Zeeuw C
in Nature Reviews Neuroscience 2012

Cerebellar ataxia by enhanced CaV2. 1 currents is alleviated by Ca2+-dependent K+-channel activators in Cacna1aS218L mutant mice

Gao Z, Todorov B, Barrett C, van Dorp S, Ferrari M, van den Maagdenberg A, De Zeeuw C, Hoebeek F
in Journal of Neuroscience 2012
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Somatic and dendritic recording of a Purkinje cell

Somatic and dendritic recording of a Purkinje cell