lab

Molecular and cellular mechanisms underlying neurodevelopmental disorders

Lab Members

Ype Elgersma
Prof.Dr. Ype Elgersma (Y)
Full Professor
Lab Head
Ben Distel
Ben Distel
Associate Professor
Edwin Mientjes
Dr. Edwin Mientjes
Postdoctoral Fellow
Diana Rotaru
Diana Rotaru
Postdoctoral Fellow
Monica Sonzogni
Monica Sonzogni
Phd Student
Martijn Kool
Martijn Kool
Phd Student
Jesminne Castricum
Jesminne Castricum
Phd Student
Myrthe Ottenhoff
Myrthe Ottenhoff
Phd Student
Stijn Bossuyt
Stijn Bossuyt
Phd Student
Mattijs Punt
Mattijs Punt
Phd Student
Linda Koene
Linda Koene
Phd Student
Andre Rietman
Drs Andre Rietman
Phd Student
Isabella Zampeta
Isabella Zampeta
Phd Student
Malika Diabaté
Malika Diabaté
Master student
Teja Kakunuri
Teja Kakunuri
Master Student
Maud de Vries
Maud de Vries
Master Student
Charlotte de Konink
Charlotte de Konink
Research Analyst
Ilse Wallaard
Ilse Wallaard
Research Analyst
Minetta Elgersma Hooisma
Minetta Elgersma Hooisma
Research Analyst

Recent Publications

Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome.

Wang T, van Woerden GM, Elgersma Y, Borst JGG
in Frontiers in cellular neuroscience 2018

Autism Spectrum Disorder in an Unselected Cohort of Children with Neurofibromatosis Type 1 (NF1).

Eijk S, Mous SE, Dieleman GC, Dierckx B, Rietman AB, de Nijs PFA, Ten Hoopen LW, van Minkelen R, Elgersma Y, Catsman-Berrevoets CE, Oostenbrink R, Legerstee JS
in Journal of autism and developmental disorders 2018

Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia.

de Vrij FM, Bouwkamp CG, Gunhanlar N, Shpak G, Lendemeijer B, Baghdadi M, Gopalakrishna S, Ghazvini M, Li TM, Quadri M, Olgiati S, Breedveld GJ, Coesmans M, Mientjes E, de Wit T, Verheijen FW, Beverloo HB, Cohen D, Kok RM, Bakker PR, Nijburg A, Spijker AT, Haffmans PMJ, Hoencamp E, Bergink V, Vorstman JA, Wu T, Olde Loohuis LM, Amin N, Langen CD, Hofman A, Hoogendijk WJ, van Duijn CM, Ikram MA, Vernooij MW, Tiemeier H, Uitterlinden AG, Elgersma Y, Distel B, Gribnau J, White T, Bonifati V, Kushner SA
in Molecular psychiatry 2018

A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel mutants.

Sonzogni M, Wallaard I, Santos SS, Kingma J, du Mee D, van Woerden GM, Elgersma Y
in Molecular autism 2018

Worries and needs of adults and parents of adults with neurofibromatosis type 1.

Rietman AB, van Helden H, Both PH, Taal W, Legerstee JS, van Staa A, Moll HA, Oostenbrink R, van Eeghen AM
in American journal of medical genetics. Part A 2018

Working Memory Training Following Neonatal Critical Illness: A Randomized Controlled Trial.

Schiller RM, Madderom MJ, van Rosmalen J, van Heijst AFJ, de Blaauw I, Utens E, Rietman AB, Verhulst F, Tibboel D, White T, IJsselstijn H
in Critical care medicine 2018

Changes in sensory processing after anesthesia in toddlers.

Berghmans JM, Poley MJ, van der Ende J, Rietman A, Glazemakers I, Himpe D, Verhulst FC, Utens E
in Minerva anestesiologica 2018

Risk Factors of Impaired Neuropsychologic Outcome in School-Aged Survivors of Neonatal Critical Illness.

Leeuwen L, Schiller RM, Rietman AB, van Rosmalen J, Wildschut ED, Houmes RJM, Tibboel D, IJsselstijn H
in Critical care medicine 2018

Regulating the human HECT E3 ligases.

Sluimer J, Distel B
in Cellular and molecular life sciences : CMLS 2018

Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability.

Reijnders MRF, Kousi M, van Woerden GM, Klein M, Bralten J, Mancini GMS, van Essen T, Proietti-Onori M, Smeets EEJ, van Gastel M, Stegmann APA, Stevens SJC, Lelieveld SH, Gilissen C, Pfundt R, Tan PL, Kleefstra T, Franke B, Elgersma Y, Katsanis N, Brunner HG
in Nature communications 2017

A brain proteomic investigation of rapamycin effects in the mouse model.

Wesseling H, Elgersma Y, Bahn S
in Molecular autism 2017

Ub3a loss increases excitability and blunts orientation tuning in the visual cortex of Angelman syndrome model mice.

Wallace ML, van Woerden GM, Elgersma Y, Smith SL, Philpot BD
in Journal of neurophysiology 2017

A versatile plasmid system for reconstitution and analysis of mammalian ubiquitination cascades in yeast.

Avagliano Trezza R, van den Burg J, van den Oever N, Distel B
in Microbial cell (Graz, Austria) 2017

Dynamic modulation of activity in cerebellar nuclei neurons during pavlovian eyeblink conditioning in mice.

Ten Brinke MM, Heiney SA, Wang X, Proietti-Onori M, Boele HJ, Bakermans J, Medina JF, Gao Z, De Zeeuw CI
in eLife 2017

Emotional and behavioral problems in children and adolescents with neurofibromatosis type 1.

Rietman AB, van der Vaart T, Plasschaert E, Nicholson BA, Oostenbrink R, Krab LC, Descheemaeker MJ, Wit MY, Moll HA, Legius E, Nijs PFA
in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2017
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The approach used to study the molecular and cellular mechanisms underlying learning and intellectual disability

The approach used to study the molecular and cellular mechanisms underlying learning and intellectual disability