lab

Understanding the role of CAMK2 in neurodevelopment and neurodevelopmental disorders

Lab Members

Geeske van Woerden
Dr. Geeske van Woerden (GM)
Assistant Professor
Lab Head
Charlotte de Konink
Charlotte de Konink
Research Analyst

Recent Publications

Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome.

Wang T, van Woerden GM, Elgersma Y, Borst JGG
in Frontiers in cellular neuroscience 2018

A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel mutants.

Sonzogni M, Wallaard I, Santos SS, Kingma J, du Mee D, van Woerden GM, Elgersma Y
in Molecular autism 2018

Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability.

Reijnders MRF, Kousi M, van Woerden GM, Klein M, Bralten J, Mancini GMS, van Essen T, Proietti-Onori M, Smeets EEJ, van Gastel M, Stegmann APA, Stevens SJC, Lelieveld SH, Gilissen C, Pfundt R, Tan PL, Kleefstra T, Franke B, Elgersma Y, Katsanis N, Brunner HG
in Nature communications 2017

Ub3a loss increases excitability and blunts orientation tuning in the visual cortex of Angelman syndrome model mice.

Wallace ML, van Woerden GM, Elgersma Y, Smith SL, Philpot BD
in Journal of neurophysiology 2017

Dynamic modulation of activity in cerebellar nuclei neurons during pavlovian eyeblink conditioning in mice.

Ten Brinke MM, Heiney SA, Wang X, Proietti-Onori M, Boele HJ, Bakermans J, Medina JF, Gao Z, De Zeeuw CI
in eLife 2017

Impaired Neurite Contact Guidance in Ubiquitin Ligase E3a (Ube3a)-Deficient Hippocampal Neurons on Nanostructured Substrates.

Tonazzini I, Meucci S, Van Woerden GM, Elgersma Y, Cecchini M
in Advanced healthcare materials 2016

GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility

Judson, M. C., Wallace, M. L., Sidorov, M. S., Burette, A. C., Gu, B., van Woerden, G. M., King, I. F., Han, J. E., Zylka, M. J., Elgersma, Y., Weinberg, R. J. and Philpot, B. D.
in Neuron 2016

The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion

Kool, M. J., Van De Bree, J. E., Bodde, H. E., Elgersma, Y. and Van Woerden, G. M.
in Scientific Reports 2016

Excitatory Cerebellar Nucleocortical Circuit Provides Internal Amplification during Associative Conditioning.

Gao Z, Proietti-Onori M, Lin Z, Ten Brinke MM, Boele HJ, Potters JW, Ruigrok TJ, Hoebeek FE, De Zeeuw CI
in Neuron 2016

Neurofibromin regulates HCN activity in Parvalbumin-positive interneurons.

Omrani A, van Woerden GM, Elgersma Y
in Molecular psychiatry 2015

An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression.

Bruinsma CF, Savelberg SM, Kool MJ, Jolfaei MA, Van Woerden GM, Baarends WM, Elgersma Y
in Human molecular genetics 2015

HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1.

Omrani A, van der Vaart T, Mientjes E, van Woerden GM, Hojjati MR, Li KW, Gutmann DH, Levelt CN, Smit AB, Silva AJ, Kushner SA, Elgersma Y
in Molecular psychiatry 2015

Distinct roles of α-and βCaMKII in controlling long-term potentiation of GABAA-receptor mediated transmission in murine Purkinje cells

Gao Z, van Woerden G, Elgersma Y, De Zeeuw C, Hoebeek F
in Frontiers in cellular neuroscience 2014

Temporal and Region-Specific Requirements of alphaCaMKII in Spatial and Contextual Learning

Achterberg, K. G., Buitendijk, G. H., Kool, M. J., Goorden, S. M., Post, L., Slump, D. E., Silva, A. J., van Woerden, G. M., Kushner, S. A. and Elgersma, Y.
in J Neurosci 2014

Distinct roles of α- and βCaMKII in controlling long-term potentiation of GABAA-receptor mediated transmission in murine Purkinje cells

Gao, Z., van Woerden, G. M., Elgersma, Y., De Zeeuw, C. I. and Hoebeek, F. E.
in Frontiers in Cellular Neuroscience 2014
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